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Vital Derma Complex
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Abstract

Background

1 Previous studies showed that supplementation of reduced form of glutathione
(GSH, 500 mg/d) has a skin-lightening efficacy in humans. This study was designed to evaluate the influences of both GSH and oxidized form (GSSG), at doses lower than 500 mg/d, on
improving skin properties

Patients and methods

2 A randomized, double-blind, placebo-controlled, parallel, three-arm
study was conducted. Healthy female subjects were equally randomized into three groups
and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks. At each visit at
baseline and for 12 weeks, skin features including melanin index, wrinkles, and other relevant
biophysical properties were measured. Blood samples were collected for safety monitoring.

Results

3 In generalized estimating equation analyses, melanin index and ultraviolet spots of
all sites including face and arm when given GSH and GSSG tended to be lower than placebo.
At some sites evaluated, subjects who received GSH showed a significant reduction in wrinkles
compared with those taking placebo. A tendency toward increased skin elasticity was observed
in GSH and GSSG compared with placebo. There were no serious adverse effects throughout
the study.

Conclusion

4 We showed that oral glutathione, 250 mg/d, in both reduced and oxidized forms
effectively influences skin properties. Overall, glutathione in both forms are well tolerated.

Let's cover the benefits

  • Increases skin hydration to the entire body surface
  • Reduces trans-epidermal water loss
  • Low effective daily dosage
  • Increases endogenous ceramide production
  • Improved skin brightness
  • Reduction in fine lines & wrinkles
  • May play a helpful role in relieving dry eye syndrome by preserving lipids from
    oxidation
  • Helps with depth perception and visual acuity in athletes
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